Insect growth regulators are generally harmless to humans and other vertebrates. Is this statement true or false?

Insect growth regulators (IGRs) are designed to target specific physiological processes in insects, which are significantly different from those in humans and other vertebrates. This specialized function allows IGRs to disrupt the normal development of pests, such as preventing them from maturing into adults or reproducing, without affecting non-target species.

The design of IGRs typically focuses on mimicking hormones involved in insect growth, like juvenile hormones or ecdysteroids, which have no equivalent in vertebrates. This biochemical specificity is what makes them an effective tool in pest management while maintaining a high safety profile for humans and other mammals. Therefore, the assertion that they are generally harmless to humans and other vertebrates holds true.

While it is essential to also consider factors such as concentration and exposure routes, the fundamental principle is that the targeted action of these compounds makes them safe for vertebrates under normal usage conditions. This underpins the correctness of the statement provided.